Recent progress understanding AD genetics in the context of the National Plan to Address AD
Alzheimer disease genetics: Where we’ve been and where we’re going
Alzheimer’s disease genetics: Gene and locus discovery and evaluation – Part 1
Alzheimer’s disease genetics: Gene and locus discovery and evaluation – Part 2
Biological pathways implicated by recent GWAS and sequencing studies
Use of genomic annotation to identify AD-related biological function
Introduction
Genetic variability and Alzheimer’s disease across Europe
AD genetics around the world: Alzheimer’s genetic research across Asia: Capturing diversity from India to Korea, China and Japan
Alzheimer’s genetic research in African populations from Ibadan to America
Recent advances in genetic studies in Alzheimer’s disease in African Americans
Alzheimer’s genetic research across the Americas — Admixture — transethnic studies
Genetic epidemiology of Alzheimer’s disease in high risk Puerto Ricans: A study on the PSEN1-G206A mutation carrier families
From genetics to clinical care and prevention: Lessons from Colombian families with autosomal dominant Alzheimer’s disease
Summary
Introduction
Gamma-secretase function, APP metabolism and the impact of APP, PSEN1 and PSEN2 variants
The amyloid pathway implicated by genetics of Alzheimer’s disease and the value of epigenetic studies
What we have learned about the amyloid cascade hypothesis and future directions: Deposited proteins mark clearance failures
Autosomal dominant Alzheimer’s disease: Primary and secondary prevention of dominantly inherited AD
Summary
Introduction
Deciphering the complex genetics of Alzheimer’s disease: From variants to mechanisms
AD susceptibility: Are peripheral or CNS myeloid cells involved?
Genetic guides directionality of immune modulation needed for benefit in Alzheimer’s disease
2 Å atomic structure and function of CD33 splice forms in relationship to AD risk
Therapeutic targeting of microglia function for AD: Novel TREM2 antibody approaches
Summary
Introduction
Pathobiology of endosomes in the etiology of Alzheimer’s disease and related disorders
The autophagy/lysosomal pathway and AD: Insights from genetics
The CD2AP susceptibility network regulates endocytosis and synaptic proteostasis in Alzheimer’s disease
Summary
Introduction
History, overview of APOE and Alzheimer’s disease
The neurobiology of APOE in relation to how it influences the pathogenesis of Alzheimer’s disease
ABCA7: Diversity in AD risk and pathogenic mechanisms
Ancestry of origin and APOE: New insights into AD risk in diverse populations
APOE2 and protective variants
Imaging and biomarker studies with APOE
Summary, clinical applications and future directions
Introduction: The importance of tau and neuronal signaling genes to deciphering Alzheimer’s disease
Genetic support for the role of MAPT and related genes in ADRD
Tau PET and CSF endophenotypes: From genetic associations to precision medicine
Biological support for MAPT (Tau) and other genes in the neuronal signaling pathway: Insights into novel pathways for disease therapy
Summary
