Agenda & Webinars (2020)

Recent progress understanding AD genetics in the context of the National Plan to Address AD

Eliezer Masliah, M.D.

Alzheimer disease genetics: Where we’ve been and where we’re going

Gary Beecham, Ph.D.

Alzheimer’s disease genetics: Gene and locus discovery and evaluation – Part 1

Gerard Schellenberg, Ph.D.

Alzheimer’s disease genetics: Gene and locus discovery and evaluation – Part 2

Gerard Schellenberg, Ph.D.

Biological pathways implicated by recent GWAS and sequencing studies

Brian Kunkle, Ph.D., M.P.H.

Use of genomic annotation to identify AD-related biological function

William S. Bush, Ph.D.


Richard Mayeux, M.D., M.P.H.

Genetic variability and Alzheimer’s disease across Europe

Jean Charles Lambert, Ph.D.

AD genetics around the world: Alzheimer’s genetic research across Asia: Capturing diversity from India to Korea, China and Japan

Sudha Seshadri, M.D.

Alzheimer’s genetic research in African populations from Ibadan to America

Hugh Hendrie, M.D.

Recent advances in genetic studies in Alzheimer’s disease in African Americans

Margaret A. Pericak-Vance, Ph.D.

Alzheimer’s genetic research across the Americas — Admixture — transethnic studies

Giuseppe Tosto, M.D., Ph.D.

Genetic epidemiology of Alzheimer’s disease in high risk Puerto Ricans: A study on the PSEN1-G206A mutation carrier families

Joseph H. Lee, Ph.D.

From genetics to clinical care and prevention: Lessons from Colombian families with autosomal dominant Alzheimer’s disease

Yakeel Quiroz, Ph.D.


Cornelia van Duijn, DPhil


Shea Andrews, Ph.D.

Gamma-secretase function, APP metabolism and the impact of APP, PSEN1 and PSEN2 variants

Lucia Chávez-Gutiérrez, Ph.D.

The amyloid pathway implicated by genetics of Alzheimer’s disease and the value of epigenetic studies

Ekaterina Rogaeva, Ph.D.

What we have learned about the amyloid cascade hypothesis and future directions: Deposited proteins mark clearance failures

John Hardy, Ph.D.

Autosomal dominant Alzheimer’s disease: Primary and secondary prevention of dominantly inherited AD

Randy Bateman, M.D.


Alan Renton, Ph.D.


Badri N. Vardarajan, Ph.D.

Deciphering the complex genetics of Alzheimer’s disease: From variants to mechanisms

Edoardo Marcora, Ph.D.

AD susceptibility: Are peripheral or CNS myeloid cells involved?

Phil De Jager, M.D., Ph.D.

Genetic guides directionality of immune modulation needed for benefit in Alzheimer’s disease

Todd Golde, M.D., Ph.D.

2 Å atomic structure and function of CD33 splice forms in relationship to AD risk

Peter St. George-Hyslop, M.D.

Therapeutic targeting of microglia function for AD: Novel TREM2 antibody approaches

Kate Monroe, Ph.D.


Alison Goate, DPhil


Bruno Benitez, M.D.

Pathobiology of endosomes in the etiology of Alzheimer’s disease and related disorders

Ralph Nixon, M.D., Ph.D.

The autophagy/lysosomal pathway and AD: Insights from genetics

Steve Finkbeiner, M.D., Ph.D.

The CD2AP susceptibility network regulates endocytosis and synaptic proteostasis in Alzheimer’s disease

Josh Shulman, M.D., Ph.D.


Carlos Cruchaga, Ph.D.


Jonathan L. Haines, Ph.D.

History, overview of APOE and Alzheimer’s disease

Michael Greicius, M.D., M.P.H

The neurobiology of APOE in relation to how it influences the pathogenesis of Alzheimer’s disease

David M. Holtzman, M.D.

ABCA7: Diversity in AD risk and pathogenic mechanisms

Holly Cukier, Ph.D.

Ancestry of origin and APOE: New insights into AD risk in diverse populations

Timothy Thornton, Ph.D.

APOE2 and protective variants

Gyungah Jun, Ph.D.

Imaging and biomarker studies with APOE

Clifford Jack, M.D.

Summary, clinical applications and future directions

Jeffery M. Vance, Ph.D., M.D.

Introduction: The importance of tau and neuronal signaling genes to deciphering Alzheimer’s disease

Lindsay Farrer, Ph.D.

Genetic support for the role of MAPT and related genes in ADRD

Jennifer Yokoyama, Ph.D.

Tau PET and CSF endophenotypes: From genetic associations to precision medicine

Andrew Saykin, PsyD

Biological support for MAPT (Tau) and other genes in the neuronal signaling pathway: Insights into novel pathways for disease therapy

Benjamin Wolozin, M.D., Ph.D.


Elizabeth Blue, Ph.D.